At BioLyo we can execute the following process steps/activities for process development and process characterization:
| Process step/activity | Equipment |
|---|---|
| Media screening studies Pre-cultures |
Plate reader/incubator/shaker Shaking incubator |
| Batch culture Fed-batch culture Perfusion culture |
8 bioreactor DasGip system (8 x 1.8 L) |
| Concentration & Diafiltration | Krosflo II filtration system |
| Controlled freezing & Lyophilization in vials and in bulk Conditional advance of lyophilization cycle using pirani/CM manometers or pressure rise tests |
LyoBeta 6 shelf lyophilizer |
| Milling using PE balls to mill bulk lyophized cake in the presence or absence of excipient | Ball mill |
| Capsule filling | Manual capsule filling unit |